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Genetically Modified Primate Models for Brain Disorder Research.

Yi Yang^1,2, Jianbang Lin^1,2, Mengqi Li¹

¹Research Center for Primate Neuromodulation and Neuroimaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.

Neuroscience Bulletin

|October 25, 2025

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This summary is machine-generated.

Genetically modified nonhuman primate (NHP) models, particularly those using gene editing, are crucial for understanding brain disorders. These advanced models accelerate the development of novel therapeutics for neurological conditions.

Area of Science:

Neuroscience
Genetics
Primate Models

Background:

Brain disorders present a growing socioeconomic challenge.
Understanding brain disorder pathogenesis and therapy development faces significant knowledge gaps.
Nonhuman primates (NHPs) offer valuable insights due to human-like neuroanatomy and neurophysiology.

Purpose of the Study:

To review the current state of genetically modified NHP research for brain disorders.
To highlight the role of gene editing in creating disease models.
To discuss the advantages of transgenic NHP models in studying disease mechanisms.

Main Methods:

Review of current literature on genetically modified NHP models in brain disorder research.
Emphasis on gene editing techniques (e.g., CRISPR-Cas9) for NHP model creation.

Keywords:

Animal models Brain disorders Gene editing Nonhuman primates

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Analysis of transgenic NHP models for mechanistic studies.

Main Results:

Genetically modified NHPs, especially through gene editing, are powerful tools for modeling brain disorders.
Transgenic NHPs provide unique advantages for dissecting complex disease mechanisms.
Significant progress has been made in developing NHP models for various neurological conditions.

Conclusions:

NHP models, particularly genetically modified ones, are essential for advancing brain disorder research.
Gene editing technologies are revolutionizing the creation of relevant NHP disease models.
Despite remaining challenges, NHPs hold immense potential for accelerating therapeutic development for brain disorders.