A unique imaging sign: tiny cysts across the brain and spine

Area of Science:

• Pediatric Oncology
• Neuroradiology
• Neuropathology

Background:

• Diffuse Leptomeningeal Glioneuronal Tumor (DLGNT) is a rare pediatric neoplasm.
• DLGNT presents with variable clinical and radiological features, often causing diagnostic delays.

Purpose of the Study:

• To report a unique case of DLGNT with a distinct radiological presentation.
• To emphasize the importance of recognizing specific imaging patterns for early DLGNT diagnosis in children.

Main Methods:

• Case presentation of a 3-year-old boy with seizures and gait disturbance.
• Brain and spine MRI analysis revealing widespread, non-enhancing, cystic lesions.
• Histopathological confirmation of DLGNT via biopsy.

Main Results:

• The patient exhibited diffuse, non-enhancing, cystic lesions along the cerebral sulci and subarachnoid space.
• Biopsy confirmed the diagnosis of Diffuse Leptomeningeal Glioneuronal Tumor (DLGNT).

Conclusions:

• DLGNT can present radiologically as diffuse, non-enhancing cystic lesions.
• Early recognition of this unique imaging pattern is vital for timely diagnosis and management of pediatric DLGNT.