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Updated: Jan 14, 2026

Microwave-assisted Intramolecular Dehydrogenative Diels-Alder Reactions for the Synthesis of Functionalized Naphthalenes/Solvatochromic Dyes
Published on: April 1, 2013
Visible-Light-Induced Monofluoromethylation of Styrenes
Zhengling Wu1, Zechao Liu1, Junrui Wang1
1Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China.
Abstract:
The allylic monofluoromethyl moiety is a structurally significant motif with well-established relevance in pharmaceutical chemistry and materials science. This study presents a streamlined and effective method for the synthesis of allylic monofluoromethylated compounds. Utilizing sulfonyl monofluoromethyl bromide as the fluoromethylating agent, the transformation is facilitated under visible-light irradiation in the presence of a cobaloxime catalyst. This approach enables the direct fluoroalkylation of alkenes, affording the desired allylic monofluoromethyl products with high efficiency. The reaction proceeds under mild conditions and exhibits a broad substrate scope, displaying excellent functional group tolerance across various biologically important molecules, including derivatives of estrone, thymol, amino acids, glucose, and ciprofibrate.
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