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Updated: Jan 14, 2026

Spectrophotometric Determination of Phycobiliprotein Content in Cyanobacterium Synechocystis
Published on: September 11, 2018
First total synthesis of cyanopterin, a pterin glycoside isolated from a cyanobacterium
Tadashi Hanaya1, Yuta Maeda1, Kazumasa Ejiri1
1Department of Chemistry, Faculty of Science, Okayama University, Tsushima-naka, Kita-ku, Okayama, 700-8530, Japan.
Abstract:
The first total synthesis and structural identification of cyanopterin, a pterin glycoside isolated from the cyanobacterium Synechocystis sp. PCC 6803, has been accomplished. The synthesis was achieved by convergent coupling of three key derivatives: d-glucuronate, d-galactose, and 6-hydroxymethylpterin. An α-selective glycosylation enabled efficient construction of the glucuronate-galactose disaccharide, while subsequent β-exclusive glycosylation with the 6-hydroxymethylpterin derivative furnished the desired pterin-disaccharide glycoside. Final deprotection provided cyanopterin in its natural form, allowing confirmation of its precise structure.
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