Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuronal dynamics and axonal flow: axonal peristalsis.

P A Weiss

    Proceedings of the National Academy of Sciences of the United States of America
    |May 1, 1972
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Anticodon domain methylated nucleosides of yeast tRNA(Phe) are significant recognition determinants in the binding of a phage display selected peptide.

    Biochemistry·2001
    Same author

    Effect of fetal hyperinsulinism on oral glucose tolerance test results in patients with gestational diabetes mellitus.

    American journal of obstetrics and gynecology·2001
    Same author

    Can glucose tolerance test predict fetal hyperinsulinism?

    BJOG : an international journal of obstetrics and gynaecology·2001
    Same author

    Cord blood oxygen saturation in vigorous infants at birth: what is normal?

    BJOG : an international journal of obstetrics and gynaecology·2000
    Same author

    Long-term follow-up of infants of mothers with type 1 diabetes: evidence for hereditary and nonhereditary transmission of diabetes and precursors.

    Diabetes care·2000
    Same author

    Low fetal oxygen saturation at birth and acidosis.

    Obstetrics and gynecology·2000

    Researchers verified the peristaltic surface drive mechanism propelling axonal columns in mouse sensory nerves. This cellular propulsion occurs at approximately 1 mm/day, driven by pulse waves every 30 minutes, even when flow is obstructed.

    Area of Science:

    • Neuroscience
    • Cell Biology
    • Biophysics

    Background:

    • Axonal transport is crucial for neuronal function and survival.
    • The mechanism of axonal propulsion, particularly at the cellular level, remains an area of active research.
    • Previous hypotheses suggested a peristaltic surface drive for axonal flow.

    Purpose of the Study:

    • To experimentally verify and quantitatively analyze the postulated peristaltic surface drive of axonal propulsion.
    • To determine the rate and characteristics of cellulifugal (away from the cell body) axonal flow.
    • To investigate the behavior of this propulsion mechanism under different conditions, including axonal disruption.

    Main Methods:

    • Time-lapse, phase-contrast cinemicrography was used to observe sensory nerve fibers from young mice.

    Related Experiment Videos

  • Nerve fibers were isolated with their originating spinal ganglia in a nutrient solution.
  • Quantitative analysis of the observed axonal movement and surface wave propagation was performed.

    • Main Results:

    • The peristaltic surface drive mechanism for cellulifugal axonal propulsion was experimentally verified.
    • Axonal columns were propelled at a rate of approximately 1 millimeter per day (1 micrometer per minute).
    • Pulse waves occurred at approximately 30-minute intervals, irrespective of axon continuity or fragmentation, and persisted even when flow was obstructed.

    Conclusions:

    • The peristaltic surface drive is a validated mechanism for the propulsion of axonal columns in sensory nerves.
    • This mechanism operates consistently, maintaining pulse wave intervals and continuing despite axonal damage or obstruction.
    • The findings provide quantitative insights into the biophysical processes governing axonal transport.