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Integration of Habitat Risk Score in Radiation Therapy for Prostate Cancer.

Evangelia I Zacharaki1, Adrian L Breto1, Ahmad Algohary1

  • 1Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, Florida.

International Journal of Radiation Oncology, Biology, Physics
|October 25, 2025
PubMed
Summary

Habitat Risk Score (HRS) maps improve prostate cancer boost radiation therapy by standardizing tumor segmentation. This multiparametric MRI technique enhances accuracy and objectivity for better patient outcomes.

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Area of Science:

  • Oncology
  • Radiology
  • Medical Physics

Background:

  • Focal radiation boost improves prostate cancer treatment effectiveness.
  • Accurate segmentation of gross tumor volume (GTVp) is crucial for boost delivery.
  • Standardized methods for GTVp contouring are needed for wider adoption of focal boost RT.

Purpose of the Study:

  • To propose Habitat Risk Score (HRS) maps for automatic GTV contouring in prostate cancer.
  • To describe a platform for integrating HRS into radiation therapy (RT) workflows.
  • To evaluate the effectiveness of HRS in improving GTVp segmentation for focal radiation boost.

Main Methods:

  • HRS is a multiparametric MRI (mpMRI) analysis technique assigning aggressiveness scores per pixel.
  • HRS was evaluated in patients undergoing RT boost, guiding GTVp segmentation using HRS6 volume.
  • Logistic regression and radiomics models assessed HRS6's ability to discriminate cancer risk and correlate with genomic signatures (Decipher).

Main Results:

  • HRS-guided biopsy yielded higher positive core rates compared to reference procedures.
  • HRS6 demonstrated significant correlation with PSA, Grade Group (GG), and Decipher (P < .0001).
  • AUCs for HRS6 in identifying clinically significant, intermediate, and high-risk cancer were 0.76, 0.81, and 0.85, respectively.

Conclusions:

  • The HRS approach standardizes and enhances tumor localization for consistent GTVp delineation.
  • HRS increases objectivity in assessment and is streamlined for broader clinical adoption.
  • This technique facilitates accurate focal radiation boost delivery in prostate cancer patients.