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Related Concept Videos

Ion Exchange01:17

Ion Exchange

1.1K
Ion exchange chromatography separates charged molecules from a solution by reversibly exchanging them with mobile, or 'active', ions associated with the oppositely charged stationary phase. This method can be used to separate ions, soften and deionize water, and purify solutions. The polymers comprising the ion-exchange column are high-molecular-weight and chemically stable polymers, crosslinked to be porous and essentially insoluble. They are also functionalized with either acidic or...
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EDTA: Chemistry and Properties01:22

EDTA: Chemistry and Properties

3.2K
Polydentate ligands are most widely used in complexometric titrations because they form more stable complexes with the metal ions than mono- or bidentate ligands due to the chelate effect. Examples of polydentate ligands are ethylenediaminetetraacetic acid (EDTA), crown ethers, and cryptands. The most important feature of optimal polydentate ligands is the ability to form 1:1 complexes in a single-step process. Amino carboxylic acid derivatives are frequently used as complexing agents. EDTA is...
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Complexation Equilibria: The Chelate Effect01:19

Complexation Equilibria: The Chelate Effect

1.1K
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
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Anionic Chain-Growth Polymerization: Overview01:20

Anionic Chain-Growth Polymerization: Overview

2.5K
The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...
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Pore Transport and Ion-Pair Transport01:17

Pore Transport and Ion-Pair Transport

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Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited  but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...
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Updated: Jan 6, 2026

Assembly and Characterization of Polyelectrolyte Complex Micelles
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Assembly and Characterization of Polyelectrolyte Complex Micelles

Published on: March 2, 2020

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Stable Polyelectrolyte Complexes Releasing Active Agents.

Arjaree Jobdeedamrong1, Daniel Crespy1

  • 1Department of Materials Science and Engineering, School of Molecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology, Rayong, Thailand.

Macromolecular Rapid Communications
|October 25, 2025
PubMed
Summary
This summary is machine-generated.

This study introduces a charge-preserving method to stabilize polyelectrolyte complexes (PECs) after active substance release. This innovation ensures PEC integrity under various conditions, enabling reliable polyelectrolyte delivery systems.

Keywords:
Coacervatescontrolled releaselayer by layerpH‐responsive materialspolyelectrolyte assembly

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Chemical Engineering

Background:

  • Polyelectrolyte complexes (PECs) are widely used in drug delivery systems.
  • Maintaining PEC stability during active substance release is challenging due to environmental factors like pH changes, dilution, and ionic stress.
  • Existing methods often struggle with long-term stability and controlled release kinetics.

Purpose of the Study:

  • To develop a novel charge-preserving strategy for stabilizing PECs post-release.
  • To demonstrate the effectiveness of this strategy in maintaining PEC integrity under various environmental stresses.
  • To enable controlled release of active substances using a durable polyelectrolyte-based delivery platform.

Main Methods:

  • A charge-preserving approach was implemented by regenerating charged species after the release of an active substance.
  • The stability of the modified PECs was tested under conditions of pH change, dilution, and ionic stress.
  • The controlled release of a corrosion inhibitor from the stabilized PECs was investigated.

Main Results:

  • The charge-preserving strategy successfully maintained the integrity of PECs after active substance release.
  • Stabilized PECs exhibited resilience against pH variations, dilution, and ionic fluctuations.
  • The approach facilitated the controlled release of a corrosion inhibitor, showcasing its potential for delivery applications.

Conclusions:

  • The charge-preserving strategy offers a robust method for stabilizing PECs in aqueous environments.
  • This technique provides a durable platform for polyelectrolyte-based delivery systems with enhanced stability.
  • The findings open new avenues for designing advanced delivery systems for various active substances.