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Laparoscopic Versus Robotic Adrenalectomy: A Randomized Clinical Trial
Eren Berber1, Arturan Ibrahimli2, Edip Memisoglu2
1Center for Endocrine Surgery, Cleveland Clinic, Cleveland, OH, USA. berbere@ccf.org.
Annals of Surgical Oncology
|October 26, 2025
Summary
Robotic adrenalectomy (RA) offers better ergonomics and fewer surgical plan conversions than laparoscopic adrenalectomy (LA). Perioperative outcomes and costs were similar between the two minimally invasive approaches.
Area of Science:
- Minimally Invasive Surgery
- Surgical Technology
- Adrenal Gland Surgery
Background:
- Robotic adrenalectomy (RA) shows promise but requires comparison with established laparoscopic adrenalectomy (LA).
- Previous studies on RA vs. LA used outdated technology or focused narrowly on specific patient groups.
Purpose of the Study:
- To compare perioperative outcomes between laparoscopic and robotic transabdominal lateral adrenalectomies.
- To evaluate the impact of surgical approach on operative time, cost, and surgeon ergonomics.
Main Methods:
- A prospective randomized clinical trial involving 54 patients undergoing lateral adrenalectomy.
- Patients were randomized to either laparoscopic adrenalectomy (LA) or robotic adrenalectomy (RA).
- Secondary outcomes included cost and surgeon ergonomics assessed via NASA-TLX and RULA.
Main Results:
- Operative times and perioperative outcomes were similar between LA and RA groups.
- Robotic adrenalectomy (RA) demonstrated significantly lower surgeon workload (NASA-TLX) and improved ergonomic scores (RULA).
- The RA group experienced fewer conversions from the planned minimally invasive approach compared to the LA group.
Conclusions:
- Laparoscopic adrenalectomy (LA) and robotic adrenalectomy (RA) show comparable perioperative outcomes and costs.
- Robotic adrenalectomy (RA) offers superior ergonomics and a reduced rate of conversion to open surgery.
- The findings support RA as a viable alternative for adrenalectomy with enhanced surgeon comfort and procedural reliability.

