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Gut-lung axis and microbiome interplay in type 2 high asthma
1College of Pharmacy, Al Ain University, Abu Dhabi, United Arab Emirates.
Expert Review of Respiratory Medicine
|October 26, 2025
Summary
The gut-lung axis influences Type-2-high asthma. Diet and microbiome interventions show promise for managing this prevalent airway disease, with multi-omic panels guiding future therapies.
Area of Science:
- Immunology
- Microbiome research
- Pulmonology
Background:
- Type-2-high asthma is the most common asthma phenotype.
- The gut-lung microbiome axis is crucial for modulating T2 immunity in asthma.
Purpose of the Study:
- To review the role of the gut-lung axis in T2-high asthma.
- To explore therapeutic strategies targeting this axis.
Main Methods:
- A comprehensive literature search (2010-2025) across multiple databases.
- Integration of human and animal studies using multi-omics (genomics, transcriptomics, metabolomics, microbiomics).
Main Results:
- Elucidation of cellular networks and communication pathways (hematogenous, lymphatic, neural) between the gut and lungs.
- Examination of the impact of diet (fiber, Mediterranean, ultra-processed foods) on the gut-lung axis.
Conclusions:
- Future therapies may combine standard asthma treatments with dietary interventions and postbiotics.
- Validated multi-omic panels are needed for personalized treatment strategies.
- Robust clinical trials are essential for integrating these approaches into routine care.
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