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Surgical Technique for the Implantation of Tissue Engineered Vascular Grafts and Subsequent In Vivo Monitoring

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Standardised Algorithm for Peri- and Postoperative Wound Management Using Fish Skin Grafts and Octenidine in

Lukas S Fiedler^1,2, Burkard M Lippert¹, Christoph Klaus³

¹Department for Otorhinolaryngology/Head and Neck, Plastic Surgery, SLK Kliniken Heilbronn, Heilbronn, Germany.

International Wound Journal

|October 26, 2025

Summary

Fish skin grafts (FSG) combined with octenidine-based antiseptics show promise for complex head and neck wound healing. This approach aids granulation and wound closure, even in challenging irradiated areas.

Keywords:

defects fish skin graft head and neck octenidine reconstructive

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Published on: September 29, 2018

Area of Science:

Regenerative Medicine
Wound Healing
Biomaterials

Background:

Complex head and neck reconstructions are challenging, especially after radiation therapy.
Fish skin grafts (FSG) offer a novel option for difficult wound healing.
Octenidine-based antiseptics have demonstrated efficacy in high-risk skin transplantation.

Purpose of the Study:

To evaluate the effectiveness of FSG combined with octenidine-based antiseptics for head and neck wound reconstruction.
To assess granulation and wound closure times in irradiated and non-irradiated wounds.
To compare outcomes with different octenidine-based antiseptic protocols.

Main Methods:

Case report series involving five patients with seven head and neck defects.
Application of fish skin grafts (FSG) to defects.
Use of octenidine-based antiseptics, including octenilin gel in three cases.
Analysis of granulation and wound closure rates, differentiating between irradiated and non-irradiated wounds.

Main Results:

Complete granulation was achieved in three patients; 66%-80% in two.
Non-irradiated wounds granulated faster (mean 16.5 days) than irradiated wounds (mean 48.8 days).
Octenilin gel use correlated with favorable healing and shorter granulation times.
Both tested octenidine-based protocols achieved satisfactory outcomes with FSG.

Conclusions:

FSG combined with octenidine-based antiseptics is a promising approach for challenging head and neck reconstructions.
While irradiated tissues showed slower healing, satisfactory outcomes were achieved.
Further prospective studies are warranted to validate these findings.