Related Experiment Video
Updated: Aug 8, 2026
08:05
Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
Dual asthmatic responses to prosopis juliflora
Annals of Allergy
|November 1, 1977
Summary
Two asthma patients allergic to Prosopis juliflora pollen experienced immediate and late allergic responses. Disodium cromoglycate prevented inhalation-induced asthma but not skin test reactions.
Area of Science:
- Allergy and Immunology
- Pulmonary Medicine
- Environmental Health
Background:
- Prosopis juliflora is a common tree in Delhi, India, known to cause allergic reactions.
- Asthma is a chronic respiratory disease characterized by airway inflammation and bronchoconstriction.
Observation:
- Two asthmatic patients with known Prosopis juliflora pollen allergy were studied.
- Both patients exhibited dual asthmatic responses (immediate and late phases) to both intradermal and inhalation challenge tests.
- The dual response pattern suggests sensitization to pollen allergens.
Findings:
- Inhalation of disodium cromoglycate successfully inhibited the dual asthma response during inhalation provocation tests.
- Disodium cromoglycate did not inhibit the immediate or late responses observed during intradermal provocation tests.
- This indicates a difference in the mechanisms or pathways involved in allergen-induced responses via inhalation versus skin exposure.
Implications:
- Disodium cromoglycate may be effective in managing Prosopis juliflora-induced asthma triggered by airborne pollen.
- The findings highlight the importance of route of allergen exposure in determining therapeutic response.
- Further research could explore targeted treatments for different types of allergic responses in asthma.
More Related Videos
Related Concept Videos
01:24Antiasthma Drugs: Methylxanthines
Theophylline, a member of the methylxanthine class of bronchodilators, has long been used in asthma management. While its exact mechanism of action is not fully understood, it is believed to have multiple effects on various cellular processes.
Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...
Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...
01:29Asthma-I: Introduction
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
01:26Asthma-II: Pathophysiology and Classification
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
01:24Asthma-III: Symptoms and Complications
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
01:28Asthma I: Introduction
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
01:13Asthma III: Clinical Manifestations
Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...