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Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat
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Clinical Features and Imaging Abnormalities of Escherichia coli Meningitis: A Nationwide Multicenter Study

Jiating Shou1,2, Xinxin Liu1, Zhiwei Xu3

  • 1Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Clinical Pediatrics
|October 27, 2025
PubMed

Insights

Pediatric Escherichia coli meningitis, common in infants, often shows imaging abnormalities. Low cerebrospinal fluid glucose and prolonged symptoms are key risk factors for these abnormalities, aiding early diagnosis.

Area of Science:

  • Pediatric Infectious Diseases
  • Neurology
  • Medical Imaging

Background:

  • Escherichia coli (E coli) meningitis is a serious infection in infants.
  • Identifying clinical features and risk factors for complications is crucial for patient outcomes.

Purpose of the Study:

  • To investigate clinical features of E coli-induced pediatric pyogenic meningitis.
  • To analyze risk factors associated with imaging abnormalities in these patients.

Main Methods:

  • A multicenter retrospective study involving 321 confirmed cases of E coli meningitis.
  • Multivariate logistic regression was used to identify independent risk factors for imaging abnormalities.

Main Results:

  • Most patients (98.8%) were 1 year or younger.
  • Imaging abnormalities were present in 63.5%, including subdural effusion/abscess, hydrocephalus, and intracranial hemorrhage.
  • Low initial cerebrospinal fluid (CSF) glucose and symptom duration >1 week were independent risk factors for abnormalities (P=.019).

Conclusions:

  • CSF glucose levels and symptom duration are vital indicators for assessing E coli meningitis severity in children.
  • These factors aid in the early diagnosis and treatment of pediatric E coli meningitis.

Keywords:
E colibacterial meningitischildrenretrospective study

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