Stem Cell Secretome Treatment Reduces Adiposity and Improves Glucose Handling During Obesity and Weight Loss in Mice
Zachary J Fennel1,2,3, Anu S Kurian1, Paul-Emile Bourrant1,4
1Diabetes & Metabolism Research Center, University of Utah, Salt Lake City, Utah, USA.
Objective:
In this study, we investigated the effects of a stem cell-derived secretome product on adiposity and tissue quality and insulin and glucose levels in obese mice and those undergoing dietary weight loss.
Methods:
Following 16 weeks of high fat diet mice received acute (4 weeks) biweekly intramuscular injections with vehicle or secretome while remaining on a high fat diet (HFD vs. HFD-S) or during weight loss upon return to a normal chow diet (HFD/WL vs. HFD/WL-S).
Results:
After 4 weeks of treatment, HFD-S mice had greater lean mass (vs HFD), muscle weights, and quadriceps myofibrillar size and improved muscle quality (capillary density and fibrosis). HFD/WL-S mice had accelerated whole-body fat loss and improved glucose handling, fasting insulin levels, and HOMA-IR. In both secretome-treated groups (HFD-S and HFD/WL-S), liver steatosis and fibrosis were improved and similar to chow controls.
Conclusions:
Together, these results support that a stem cell secretome treatment may be useful to improve tissue quality and metabolic health during obesity and weight loss.
Insights
Stem cell secretome treatment improved tissue quality and metabolic health in obese mice. This therapy enhanced lean mass, muscle quality, and fat loss, while improving liver and glucose metabolism.
Area of Science:
- Biomedical Research
- Regenerative Medicine
- Metabolic Disease Research
Background:
- Obesity is linked to poor tissue quality and metabolic dysfunction.
- Weight loss can be challenging and may not fully restore metabolic health.
- Stem cell secretome products offer potential therapeutic benefits.
Purpose of the Study:
- To evaluate the impact of a stem cell secretome on adiposity and tissue quality in obese mice.
- To assess the effects of secretome treatment during dietary weight loss.
- To analyze changes in insulin sensitivity and glucose metabolism.
Main Methods:
- Obese mice on a high-fat diet (HFD) received intramuscular secretome injections for 4 weeks.
- A separate group underwent weight loss on a normal chow diet with secretome treatment.
- Control groups received vehicle injections under similar dietary conditions.
Main Results:
- Secretome treatment in HFD mice increased lean mass and muscle quality, reducing fibrosis.
- In weight-loss mice, secretome accelerated fat loss and improved glucose and insulin levels.
- Both secretome groups showed reduced liver steatosis and fibrosis, comparable to controls.
Conclusions:
- Stem cell secretome therapy shows promise for improving tissue quality during obesity.
- Secretome treatment aids metabolic health recovery during weight loss.
- This approach may be beneficial for managing obesity-related complications.
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