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Preferred Retinal Locus in Juvenile Macular Dystrophy.

Murat Erbezci1, Zühal Özen Tunay2, Taylan Öztürk3

  • 1Private Practice, İzmir, Türkiye.

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|October 27, 2025
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Summary
This summary is machine-generated.

Juvenile macular dystrophy (JMD) patients show preferred retinal locus (PRL) locations shifting with age, impacting visual acuity. Understanding these PRL changes is key for vision rehabilitation.

Keywords:
Maculacentral scotomajuvenile macular degenerationlow vision

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Genetics

Background:

  • Juvenile macular dystrophy (JMD) is a group of inherited retinal diseases causing progressive central vision loss.
  • The preferred retinal locus (PRL) is the retinal area used for fixation in the presence of a central scotoma.

Purpose of the Study:

  • To investigate the location of foveal lesions and PRLs in JMD patients.
  • To determine the impact of PRL location and foveal lesions on visual acuity in JMD.

Main Methods:

  • Retrospective analysis of 14 JMD patients (28 eyes) with bilateral central vision loss.
  • Evaluation of best-corrected visual acuity (BCVA), macular lesion characteristics, and PRL location/stability using scanning laser ophthalmoscope/optical coherence tomography.

Main Results:

  • PRLs were predominantly superiorly (64.3%) or nasally (35.7%) located.
  • PRL location correlated with age: nasal PRLs in younger patients (mean 15.1 years), superior PRLs in older patients (mean 22.4 years).
  • Worse visual acuity was associated with larger lesion size and increased PRL-fovea distance, which was longer in younger patients.

Conclusions:

  • PRL locations in JMD patients are typically superior or nasal and vary with age.
  • Younger JMD patients have more peripheral PRLs and poorer visual acuity, suggesting age-related cortical adaptation.
  • Characterizing PRLs in JMD is vital for developing targeted low-vision rehabilitation strategies.