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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
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Accelerated Aging Predicts Earlier Onset of Ischemic Stroke: A Proteomic and Transcriptomic Investigation
Amy May Lin Quek1,2, Ooiean Teng2, Tuan Zea Tan3
1Division of Neurology, Department of Medicine, National University Hospital, Singapore.
European Journal of Preventive Cardiology
|October 27, 2025
Summary
Accelerated aging is linked to a higher risk of ischemic stroke, appearing years earlier in affected individuals. This biological aging process may be a key factor in stroke development.
Area of Science:
- Gerontology
- Neurology
- Genomics
Background:
- Ischemic stroke incidence is rising in younger adults globally.
- Accelerated aging is a potential contributing factor to stroke risk.
Purpose of the Study:
- To investigate the clinical and molecular associations of accelerated aging in ischemic stroke patients.
- To determine if accelerated aging is an independent risk factor for ischemic stroke.
Main Methods:
- Developed proteomic models using Olink® Explore 1536 data to estimate biological age in healthy individuals.
- Applied biological age models to 679 ischemic stroke patients and defined accelerated aging.
- Utilized next-generation RNA sequencing to explore aging-related pathways in stroke patients.
Main Results:
- Nearly 40% of ischemic stroke patients exhibited accelerated aging, with stroke occurring 8.9 years earlier on average.
- Biological age increased post-stroke, and advanced biological age was associated with higher stroke odds in younger patients.
- RNA sequencing revealed differential gene expression and enriched olfactory-signaling and sensory-perception pathways in accelerated aging patients.
Conclusions:
- Accelerated aging is an independent risk factor for ischemic stroke.
- Further research into the mechanisms of accelerated aging is needed for targeted interventions.
- Understanding biological aging may offer new strategies for stroke prevention and treatment.
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