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Research priorities on physical-mental comorbidity in children and adolescents: an international consensus

Denan Jiang1,2, Jiali Zhou1, Yajie Zhu3

  • 1School of Public Health, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Eclinicalmedicine
|October 27, 2025
PubMed

Insights

Physical-mental comorbidity in children and adolescents requires a coordinated research agenda. Top priorities include treatment, early intervention, equity, and community-based support strategies.

Area of Science:

  • Child and Adolescent Health
  • Mental Health Research
  • Global Health Priorities

Background:

  • Physical-mental comorbidity in youth is a growing global concern.
  • Existing research is fragmented, lacking a unified global agenda.
  • Addressing this comorbidity is crucial for child well-being.

Purpose of the Study:

  • To establish global research priorities for child and adolescent physical-mental comorbidity.
  • To develop a strategic roadmap for future research and policy.
  • To identify key areas for intervention and support.

Main Methods:

  • Utilized the Child Health and Nutrition Research Initiative (CHNRI) method for global priority setting.
  • Involved 45 experts scoring 134 research ideas against five criteria.
  • Criteria included answerability, effectiveness, paradigm shift potential, implementation, and equity impact.

Main Results:

  • Highest-ranked research priorities focus on treatment strategies and early intervention.
  • Reducing health disparities and the role of schools/communities were identified as key.
  • Comparative analysis showed shared and context-specific needs across income levels.

Conclusions:

  • This study presents the first global consensus on research priorities for child and adolescent physical-mental comorbidity.
  • The findings provide a strategic roadmap to guide future research and policy development.
  • A coordinated approach is essential to address this complex health issue.

Keywords:
Child and adolescent healthGlobal healthPhysical-mental comorbidityResearch prioritization

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