A Case Report of Tislelizumab-Induced Lichen Planus Pemphigoides

Lichen planus pemphigoides (LPP) is a rare autoimmune subepidermal bullous disorder characterized by lichenoid lesions resembling lichen planus (LP) and bullous pemphigoid(BP). LPP may be triggered by medications, malignancies, or viral infections. Herein, we present a 67-year-old male patient with brain-metastatic non-small cell lung cancer (NSCLC) who developed pruritic violaceous plaques, tense bullae, and verrucous hyperplasia on the trunk and extremities following tislelizumab therapy. Histopathological examination confirmed LPP. The condition significantly improved with methylprednisolone combined with dupilumab treatment, and there was no recurrence during a 10-month follow-up.