Diagnosing autism spectrum disorder based on eye tracking technology using deep learning models

Mosleh Hmoud Al-Adhaileh1,2, Saleh N M Alsubari3, Abdullah H Al-Nefaie1,4

  • 1King Salman Center for Disability Research, Riyadh, Saudi Arabia.

Frontiers in Medicine
|October 27, 2025
PubMed

Insights

This study uses deep learning and eye-tracking data to accurately diagnose Autism Spectrum Disorder (ASD) in children. The advanced AI model achieved 99.78% accuracy, offering a promising tool for clinical diagnosis.

Area of Science:

  • Neuroscience
  • Computer Science
  • Developmental Psychology

Background:

  • Children with Autism Spectrum Disorder (ASD) experience challenges with social communication, particularly maintaining eye contact.
  • Eye-tracking (ET) technology offers precise, real-time insights into visual social attention patterns.
  • Identifying reliable biomarkers for ASD is crucial for early intervention and support.

Purpose of the Study:

  • To implement deep learning (DL) algorithms for analyzing eye-tracking data in children with ASD.
  • To develop an AI-driven system for the accurate diagnosis of ASD using social attention metrics.

Main Methods:

  • Utilized standard eye-tracking datasets from individuals with and without ASD.
  • Applied Convolutional Neural Networks (CNNs) and Long Short-Term Memory (LSTM) models for data analysis.
  • Employed data preprocessing, feature selection (mutual information), and CNN-LSTM models for ASD diagnosis evaluation.

Main Results:

  • The CNN-LSTM model achieved a diagnostic accuracy of 99.78%.
  • The proposed deep learning approach demonstrated superior performance compared to previous studies.
  • The system successfully identified individuals with ASD based on eye-tracking data.

Conclusions:

  • The developed system effectively diagnoses ASD using eye-tracking data and deep learning.
  • This AI-powered approach shows significant potential for clinical application in ASD diagnosis.
  • The technology can assist healthcare professionals in achieving more accurate and efficient ASD diagnoses.
Abstract

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