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Diagnostic value of metagenomic next-generation sequencing in atypical brucellosis: a case report
Dungaowa Ao1, Xinle Li2, Guoliang Zhang1
1Affiliated Hospital, Inner Mongolia Minzu University, Tongliao, China.
Background:
Brucellosis with atypical presentations, such as submandibular abscess without fever, is frequently misdiagnosed.
Methods:
Metagenomic next-generation sequencing (mNGS) was applied to pus samples from a 47-year-old female with a treatment-refractory submandibular abscess and a history of livestock exposure; results were confirmed serologically.
Results:
Within 48 h, mNGS identified Brucella suis-representing, to our knowledge, the first reported afebrile submandibular infection caused by this pathogen. Targeted therapy with doxycycline and rifamycin led to symptom resolution within 6 days.
Conclusion:
This case highlights that mNGS, combined with a thorough epidemiological history, can resolve diagnostic dilemmas in atypical brucellosis, guide precise treatment, and mitigate antibiotic misuse.
