Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

2.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

3% diquafosol sodium combined with 0.1% fluorometholone for postoperative dry eye in pterygium patients with preoperative tear deficiency: a pilot retrospective study.

Frontiers in medicine·2026
Same author

The efficacy of intermittent metformin plus lifestyle intervention for diabetes prevention in women with prediabetes and prior gestational diabetes: a randomized clinical, non-inferiority trial.

BMC medicine·2026
Same author

Long-term outcomes of one-stop unilateral thoracoscopic hybrid ablation for persistent atrial fibrillation after failed catheter ablation.

Journal of cardiothoracic surgery·2026
Same author

MAPLE: interpretable deep learning identifies selective antimicrobial peptides using joint evolutionary-physicochemical analysis.

Briefings in bioinformatics·2026
Same author

DDMPI: Diffusion Denoising for Magnetic Particle Imaging at the Low Concentration.

IEEE transactions on image processing : a publication of the IEEE Signal Processing Society·2026
Same author

Photo-switchable supramolecular glycochips for capturing suspension tumor cells and real-time profiling of cell surface glycosylation.

The Analyst·2026

Related Experiment Video

Updated: Jan 14, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

1.0K

TP-P1-Loaded Thermosensitive Hydrogel Attenuates Rheumatoid Arthritis in a Mouse Model via TLR4/NF-κB Pathway.

Fengnan Wang1,2, Zhongxiao Hu1,2, Jing Yang1,2

  • 1Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210029, People's Republic of China.

Journal of Inflammation Research
|October 27, 2025
PubMed
Summary

This study shows that a novel thermosensitive hydrogel (TPTH) loaded with TP-P1 effectively reduces inflammation and oxidative stress in rheumatoid arthritis (RA) models. The treatment demonstrated significant therapeutic benefits without causing observable liver or kidney damage.

Keywords:
TP-P1-loaded thermosensitive hydrogelanti-inflammatoryantioxidant stress capacityrheumatoid arthritis

More Related Videos

A Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model
11:03

A Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model

Published on: October 30, 2019

8.9K
Murine Model of Epicutaneously-Induced Immunomodulation
09:07

Murine Model of Epicutaneously-Induced Immunomodulation

Published on: June 24, 2025

488

Related Experiment Videos

Last Updated: Jan 14, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

1.0K
A Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model
11:03

A Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model

Published on: October 30, 2019

8.9K
Murine Model of Epicutaneously-Induced Immunomodulation
09:07

Murine Model of Epicutaneously-Induced Immunomodulation

Published on: June 24, 2025

488

Area of Science:

  • Immunology
  • Pharmacology
  • Biomaterials

Background:

  • Rheumatoid arthritis (RA) is a chronic autoimmune disease causing joint destruction due to inflammation and oxidative stress.
  • Current treatments may have side effects, necessitating exploration of novel therapeutic strategies.

Purpose of the Study:

  • To investigate the anti-inflammatory and antioxidant potential of a thermosensitive hydrogel (TPTH) containing TP-P1 for rheumatoid arthritis (RA).
  • To evaluate the therapeutic efficacy and biosafety of TPTH in a collagen-induced arthritis (CIA) mouse model.

Main Methods:

  • A CIA mouse model was established and treated intra-articularly with TPTH, dexamethasone, or controls for 28 days.
  • Arthritis severity, inflammatory cytokine levels (IL-6, IL-1β, TNF-α), oxidative stress markers (MDA, SOD, CAT, GSH), and TLR4/NF-κB signaling pathway were assessed.
  • Biosafety was evaluated through liver and kidney histology and plasma biochemical indices.

Main Results:

  • TPTH treatment significantly reduced paw swelling and arthritis scores in CIA mice (p < 0.0001).
  • TPTH downregulated pro-inflammatory cytokines, improved antioxidant status, and decreased lipid peroxidation.
  • The treatment suppressed TLR4 and NF-κB expression, indicating modulation of key inflammatory pathways, with no significant hepatic or renal toxicity observed.

Conclusions:

  • TPTH effectively ameliorates inflammation and oxidative stress in a preclinical RA model.
  • Modulation of the TLR4/NF-κB pathway is a key mechanism of TPTH's therapeutic action.
  • TPTH presents a promising, safe, and effective therapeutic strategy for managing rheumatoid arthritis.