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Nuclear Pleomorphism in Gastrointestinal Stromal Tumors: Insights Beyond Risk Stratification

Subramaniam Ramkumar1

  • 1Pathology, Nazareth Hospital, Shillong, IND.

Cureus
|October 27, 2025
PubMed
Summary

Gastrointestinal stromal tumors (GISTs) can exhibit significant nuclear pleomorphism. This case report emphasizes its importance in GIST prognosis, even without other high-grade features.

Keywords:
epithelioid featuresgastrointestinal stromal tumor (gist)histomorphologymitotic indexnuclear pleomorphismpdgfrapleomorphic gistprognostic factorssdhspindle cell morphology

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