Nuclear Pleomorphism in Gastrointestinal Stromal Tumors: Insights Beyond Risk Stratification

Gastrointestinal stromal tumors (GISTs) are very common mesenchymal neoplasms involving the gastrointestinal tract. Despite having a uniform nuclear morphology, they can show varied histological subtypes. The prognosis is based on tumor size, mitotic rate and location of the tumor. Some cases of GIST can however show marked nuclear pleomorphism. Here we report a case of GIST with marked nuclear pleomorphism without other high-grade features. This case highlights the importance of nuclear pleomorphism and its implications in the perspective of existing prognostic criteria.