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Updated: Jan 14, 2026

Four-Dimensional CT Analysis Using Sequential 3D-3D Registration
Published on: November 23, 2019
A phantom study of internal target volume and mid-position accuracy in adaptive and conventional four-dimensional
Bart J J Kremers1, Dave S C van Gruijthuijsen1, Dominique Reijtenbagh1,2
1Department of Radiation Oncology, Catharina Hospital Eindhoven, Eindhoven, Netherlands (the).
Abstract:
This technical note evaluates the performance of an adaptive four-dimensional computed tomography (4DCT) acquisition method compared to conventional 4DCT using a motion phantom. Metrics assessed include deviations in volume, CT number, diameter, peak-to-peak amplitude and determination of the internal target volume (ITV) and mid-position. Under regular breathing, most measurements fall within predefined clinical tolerances for all systems. Under irregular motion, the adaptive method showed reduced deviations in ITV and minimal impact on mid-position determination. These findings support the clinical value of adaptive 4DCT in improving motion management and target definition accuracy in radiotherapy planning.
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