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Pediatric Asthma: Questions and Answers

Salavoura Aikaterini1

  • 1Children's Hospital 'Agia Sophia', Athens, Greece.

Sage Open Pediatrics
|October 27, 2025
PubMed

Insights

This review provides an overview of asthma, covering its definition, phenotypes, endotypes, and management strategies. It highlights new insights into asthma mechanisms for improved patient care.

Area of Science:

  • Pulmonology
  • Clinical Medicine

Background:

  • Asthma is a common respiratory disease with significant morbidity and mortality.
  • Current management, guided by GINA, benefits from understanding disease phenotypes and endotypes.

Purpose of the Study:

  • To provide a comprehensive overview of asthma, integrating current literature.
  • To structure knowledge on asthma management, particularly for complex cases.

Main Methods:

  • A critical review of relevant literature was conducted.
  • PubMed database was utilized for literature retrieval.

Main Results:

  • Asthma management is evolving with new data on disease mechanisms.
  • Phenotypes, endotypes, biomarkers, genetics, and environmental factors are key to a systematic approach.

Conclusions:

  • Understanding asthma phenotypes and endotypes is crucial for managing complex cases.
  • Newer insights into asthma development support a more systematic management strategy.
  • The review discusses definition, phenotypes, endotypes, biomarkers, genetics, environment, prevention, and treatment.
Abstract

Keywords:
asthmain practice

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