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Updated: Jan 14, 2026

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Soluble Glycoprotein 130Fc Reduces Controlled Cortical Impact-Induced Cognitive Deficits in Rats.

Ashley L Russell1,2, Emma G Dimeo1,2,3, Anisha Mandava1,2,3

  • 1Department of Physical Medicine and Rehabilitation, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Neurotrauma Reports
|October 27, 2025
PubMed
Summary

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Soluble glycoprotein (sgp)130Fc treatment improved spatial learning and memory in rats after traumatic brain injury (TBI). While not reducing lesion size, sgp130Fc shows potential for TBI cognitive recovery.

Area of Science:

  • Neuroscience
  • Neurotrauma
  • Pharmacology

Background:

  • Traumatic brain injury (TBI) can cause cognitive dysfunction.
  • Interleukin-6 (IL-6) trans-signaling exacerbates neurodegeneration.
  • Soluble glycoprotein (sgp)130 inhibits IL-6 trans-signaling, reducing neuroinflammation.

Purpose of the Study:

  • To evaluate the efficacy of sgp130Fc in improving cognitive recovery after severe TBI in rats.
  • To assess the impact of sgp130Fc on neural damage and motor function post-TBI.

Main Methods:

  • A controlled cortical impact (CCI) model of severe TBI was used in male rats.
  • Rats received sgp130Fc or vehicle (VEH) starting 1 day post-injury.
  • Motor function, spatial learning/memory (Morris water maze), and lesion volume were assessed.
Keywords:
Morris water mazebehaviorinflammationinterleukin-6soluble glycoprotein 130traumatic brain injury

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Main Results:

  • sgp130Fc did not significantly alter motor deficits or lesion volume.
  • TBI rats treated with VEH showed impaired spatial learning and memory compared to shams.
  • sgp130Fc treatment significantly improved spatial learning and memory in TBI rats by post-injury day 18.

Conclusions:

  • sgp130Fc demonstrates therapeutic potential for enhancing cognitive recovery following TBI.
  • The mechanism may involve mitigating IL-6 trans-signaling effects on cognition, independent of lesion volume reduction.