"Inside CKD" Multinational-Microsimulation Modelling Insights Into the Increasing CKD Burden

Area of Science:

• Nephrology
• Public Health
• Health Economics

Background:

• Chronic kidney disease (CKD) is a global health concern, impacting approximately 10% of the world's population.
• CKD is linked to higher morbidity and mortality rates but often remains underdiagnosed and undertreated.
• It faces less attention compared to other noncommunicable diseases.

Purpose of the Study:

• To project the clinical and economic burden of CKD using the Inside CKD microsimulation model.
• To assess published Inside CKD data from 31 countries within the framework of global guidelines and initiatives.
• To evaluate the cost-effectiveness and impact of CKD screening on life expectancy.

Main Methods:

• Utilized the Inside CKD microsimulation model to forecast disease progression and costs.
• Analyzed existing published data from the Inside CKD program across 31 diverse countries and regions.
• Evaluated findings in relation to current clinical guidelines and international health strategies.

Main Results:

• Without improved diagnosis rates, the CKD population is expected to grow by 5.8% by 2027.
• Associated healthcare expenditures are projected to increase by 9.3% within the same timeframe.
• CKD screening is identified as a cost-effective intervention that can modestly enhance life expectancy.

Conclusions:

• Early identification of CKD through screening and treatment strategies is essential.
• Addressing clinical inertia in CKD diagnosis and management is crucial for mitigating its impact.
• Proactive implementation of screening and treatment is key to managing the growing burden of CKD.