Related Experiment Video
Updated: Jan 14, 2026
Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
Published on: June 6, 2025
Efficacy of cerebellar cathodal transcranial direct current stimulation for post-stroke aphasia: A randomized
Xiaoyi Xu1,2,3,4, Shuping Chen1,2,5,6, Zifan Li1,2,3,4
1Center of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Objective:
Growing evidence highlights the cerebellum, particularly the right posterior lobule, in advanced language processes such as fluency, syntax, and phonological memory. However, its specific role in post-stroke aphasia recovery-especially its modulation of cortical networks and functional connectivity (FC)-remains unclear, which limits targeted intreventions.
Methods:
Sixteen post-stroke aphasia patients were randomized to receive either cerebellar transcranial direct current stimulation (tDCS) with speech therapy or sham stimulation with therapy. Language performance was assessed via the Chinese Standard Aphasia Scale (CRRCAE), and brain activation was monitored using functional near-infrared spectroscopy (fNIRS).
Results:
Both groups showed significant CRRCAE score improvements post-treatment (P < 0.05), without between-group differences (P > 0.05). FC reductions were noted across several interhemispheric and right-hemispheric pathways, while increased FC was observed in left hemisphere language-related areas.
Conclusion:
After baseline adjustment, the intervention group showed superior gains. Cerebellar tDCS modulates FC, suggesting a potential mechanism for enhancing aphasia recovery.
Significance:
Findings support the cerebellum as a promising neuromodulation target for post-stroke aphasia treatment.
