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Published on: July 18, 2025
767
Magnetically Actuated Soft Electrodes for Multisite Bioelectrical Monitoring of Ex Vivo Tissues
Qianbi Peng1,2, Jianping Huang2,3, Chenyang Li2,3
1Guangdong Provincial Key Lab of Robotics and Intelligent Systems, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Cyborg and Bionic Systems (Washington, D.C.)
|October 27, 2025
Summary
A new magnetically actuated soft electrode (MSE) precisely navigates and records from dynamic tissues. This technology enables high-fidelity electrophysiological monitoring for drug toxicity screening and cardiovascular research.
Area of Science:
- Biomedical Engineering
- Electrophysiology
- Materials Science
Background:
- Conventional microelectrode arrays struggle with dynamic, curved ex vivo tissue surfaces.
- Accurate electrophysiological monitoring is crucial for basic research and drug toxicity evaluation.
Purpose of the Study:
- To develop a magnetically actuated soft electrode (MSE) for precise, adaptive multisite electrophysiological monitoring.
- To overcome limitations of rigid electrodes on dynamic biological tissues.
Main Methods:
- Developed a magnetically actuated soft electrode (MSE) capable of "locate-adhere-record-detach" cycles.
- Integrated magnetic locomotion with electrophysiological sensing for programmable navigation.
- Tested the MSE on beating ex vivo rat heart tissue.
Main Results:
- Achieved millimeter-level navigation accuracy and stable attachment on dynamic tissues.
- Acquired high-fidelity electrophysiological signals with a high signal-to-noise ratio (average 28 dB).
- Demonstrated continuous multisite detection on beating ex vivo tissues.
Conclusions:
- The MSE platform offers programmable, actively addressable multisite electrophysiological monitoring.
- This technology has broad potential for cardiotoxicity screening and cardiovascular research.
- Enables advanced monitoring of organ models, tissue slices, and engineered constructs.
