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Related Concept Videos

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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
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Related Experiment Video

Updated: Jan 14, 2026

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
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Comparative effectiveness of multiple different non-pharmacologic interventions for post-stroke constipation: a

Sisi Feng1, Xinhui Wu1, Xuemei Dai1

  • 1Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

Frontiers in Neurology
|October 27, 2025
PubMed
Summary

Acupoint catgut embedding (ACE) is the most effective non-pharmacological treatment for post-stroke constipation (PSC), followed by physiotherapy (PT). These interventions improve clinical outcomes and reduce constipation severity in stroke patients.

Keywords:
Bayesian network meta-analysisalternative therapiesnon-pharmacologic interventionspost-stroke constipationrehabilitation

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Area of Science:

  • Neurology
  • Gastroenterology
  • Integrative Medicine

Background:

  • Post-stroke constipation (PSC) is a frequent complication, worsening stroke severity and prognosis.
  • Straining during defecation increases intracranial pressure, risking secondary strokes and contributing to psychological distress.
  • Optimal non-pharmacological interventions (NPIs) for PSC require clarification.

Purpose of the Study:

  • To identify the most effective NPIs for improving clinical outcomes in post-stroke constipation patients.
  • To provide clinical guidance for managing PSC using NPIs.

Main Methods:

  • Bayesian network meta-analysis (NMA) of randomized controlled trials.
  • Evaluation of eight NPIs: acupuncture therapy (AT), acupoint catgut embedding (ACE), auricular therapy (ART), moxibustion (MT), abdominal massage (AM), point application (PA), physiotherapy (PT), and cognitive behavioral therapy (CBT).
  • Primary outcome: clinical effective rate (CER); Secondary outcome: Constipation Scoring System (CCS).

Main Results:

  • Analysis of 53 studies with 5,813 participants.
  • Acupoint catgut embedding (ACE) demonstrated the highest efficacy for both CER and CCS.
  • Physiotherapy (PT) ranked second in efficacy for both outcomes.

Conclusions:

  • Acupoint catgut embedding (ACE) shows potential as a superior NPI for PSC management.
  • Physiotherapy (PT) is also a highly effective intervention for PSC.
  • Further high-quality, multicenter trials are recommended to validate these findings.