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Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches
Published on: May 6, 2015
Treatment of Severe Adenovirus Infection With HAdV-B21 in a Young Obese Male With Normal Immunity
Ji Peng1, Zhen Wang2, Shili Zhong2
1Chongqing Red Cross Hospital Chongqing PR China.
Abstract:
Adenovirus infections are usually mild, but rare serotypes like "HAdV-B21" can cause severe pneumonia even in healthy individuals. We report a 32-year-old immunocompetent obese male who developed life-threatening HAdV-B21 pneumonia (PaO2/FiO2 62 mmHg), requiring mechanical ventilation. Successful treatment included ribavirin, corticosteroids, and prone positioning, avoiding ECMO. This case demonstrates the potential severity of rare adenovirus strains and supports combined antiviral/anti-inflammatory therapy for such infections.
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