Rehabilitation for functional enhancement of myasthenia gravis: A systematic review and meta-analysis

Myasthenia gravis (MG) is a rare neuromuscular disorder that causes muscle weakness and fatigue. This review evaluated the current evidence on the efficacy, tolerance and adherence of rehabilitative interventions. Based on the PRISMA guidelines, 445 articles were identified from major scientific databases. After applying the inclusion and exclusion criteria, 6 studies were included in the final analysis. Two primary rehabilitative strategies - physical and respiratory training - were identified. The results of the systematic review and meta-analysis showed that both interventions improved functional capacity and enhanced the quality of life, with good tolerance and high adherence. This review summarizes the effects of rehabilitative interventions on improving 6-min walk distance (6MWD), quality of life (MG-QOL15), and respiratory function (FEV1 and FVC) in MG patients. One study was rated as high quality (OCEBM level 1b), and five as moderate quality (OCEBM level 2b). Five findings were established and rated as Grade B, according to the OCEBM recommendations. This review demonstrated the potential of structured rehabilitation programs to improve functioning and quality of life in patients with MG, while highlighting the need for further research to optimize and standardize these interventions.