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Physiology Lab Demonstration: Glomerular Filtration Rate in a Rat
Published on: July 26, 2015
Determination of glomerular function in advanced renal failure
Archives of Disease in Childhood
|September 1, 1977
Summary
Estimating glomerular filtration rate in children with advanced chronic renal failure is crucial. Inulin clearance, creatinine clearance, urea clearance, and 51-chromium edetic acid (EDTA) clearance were compared, finding that 24-hour 51Cr-EDTA and mean creatinine/urea clearance are acceptable estimates.
Area of Science:
- Nephrology
- Pediatric Nephrology
- Renal Physiology
Background:
- Accurate assessment of glomerular filtration rate (GFR) is vital for managing chronic renal failure in children.
- Various methods exist for GFR determination, but their reliability in advanced pediatric renal failure requires validation.
Purpose of the Study:
- To compare different methods for determining glomerular filtration rate (GFR) in children with advanced chronic renal failure.
- To identify reliable and acceptable methods for estimating true GFR in this patient population.
Main Methods:
- Glomerular filtration rate was measured in 15 children with advanced chronic renal failure using inulin clearance.
- Creatinine clearance, urea clearance, and 51-chromium edetic acid (51Cr-EDTA) clearance were measured and compared to inulin clearance.
Main Results:
- Inulin clearance showed good correlation with the mean of creatinine and urea clearance.
- A strong correlation was also observed between inulin clearance and 24-hour 51Cr-EDTA clearance.
- Absolute values of creatinine clearance and shorter-term (up to 8 hours) 51Cr-EDTA clearance were higher than inulin clearance.
Conclusions:
- In children with advanced chronic renal failure, 24-hour 51Cr-EDTA clearance provides an acceptable estimate of true GFR.
- The mean of creatinine and urea clearance also serves as a reliable estimate of true GFR in this clinical context.
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