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Updated: Jan 14, 2026
Use of Electromagnetic Navigational Transthoracic Needle Aspiration E-TTNA for Sampling of Lung Nodules
Published on: May 23, 2015
Active breathing coordinator combines with custom-designed puncture needle improves diagnostic accuracy of ≤20 mm
Yuting Huang1, Jie Yang2, Peisen Liu3
1Department of Radiotherapy, Fourth Affiliated Hospital of Anhui Medical University, Hefei, China.
Background:
CT-guided percutaneous transthoracic needle biopsy (PTNB) is still the main way for obtaining pathological diagnoses of pulmonary nodules. However, the small size and respiratory-induced motion reduce diagnostic accuracy for patients with small pulmonary nodules (≤20mm). In this study, we aimed to improve biopsy precision and diagnostic accuracy for patients with small pulmonary nodules via introducing significant refinements.
Methods:
122 patients with ≤20mm pulmonary nodules were enrolled and randomly assigned to the ABC-NG PTNB group and CT-guided PTNB group. The CT-guided PTNB group underwent conventional CT-guided PTNB, while the ABC-NG PTNB group received additional ways including thermoplastic immobilization, active breathing coordinator (ABC), and a custom-designed puncture needle. Puncture accuracy, diagnostic accuracy, and complication rates were compared between the two groups.
Results:
The ABC-NG PTNB group was superior to the CT-guided PTNB group in the terms of angle error, craniocaudal plane error, positioning error, diagnostic accuracy, and one-puncture success rate (P < 0.05). The ABC-NG PTNB group had fewer punctures, fewer CT scans, lower radiation doses, and lower incidence of pneumothorax as compared to CT-guided PTNB group (P < 0.05). Furthermore, diagnostic accuracy was particularly enhanced in cases where the puncture angle was non-zero or when the nodules were located in the lower lung lobes (P < 0.05).
Conclusion:
Ct-guided PTNB combined with ABC and custom-designed puncture needle guide improves the accuracy and diagnosis rate of ≤20mm pulmonary nodule biopsy, especially nodules are located in the lower lung lobe or require a non-zero puncture angle.
