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Maternal circulating GPIHBP1 levels and neonatal outcomes in patients with gestational diabetes mellitus: a pilot
Mayu Watanabe1,2, Jun Wada2, Naoko Kurooka2
1Department of Diabetology and Endocrinology, National Hospital Organization (NHO) Okayama Medical Center, Okayama, Japan.
Insights
Circulating GPIHBP1 levels were unchanged in women with gestational diabetes mellitus (GDM) during the third trimester. These levels correlated with adverse perinatal outcomes, including lower birth weight and umbilical venous pO2.
Area of Science:
- Endocrinology
- Metabolic disorders
- Pregnancy complications
Background:
- Gestational diabetes mellitus (GDM) prevalence is rising, linked to hyperglycemia, dyslipidemia, and endothelial dysfunction.
- Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1) is vital for processing triglyceride-rich lipoproteins via lipoprotein lipase (LPL).
Purpose of the Study:
- To evaluate circulating GPIHBP1 levels during pregnancy in women with GDM.
- To assess associations between GPIHBP1, hypertriglyceridemia, and perinatal outcomes in GDM.
Main Methods:
- Comparative study involving 12 pregnant women with GDM and 21 with normal glucose tolerance (NGT).
- Measurement of circulating GPIHBP1 levels across trimesters and at delivery.
Main Results:
- No significant differences in obstetrical outcomes between GDM and NGT groups.
- In NGT, GPIHBP1 levels decreased from the 2nd to 3rd trimester and delivery.
- In GDM, third-trimester GPIHBP1 levels remained stable and negatively correlated with neonatal birth weight percentile and umbilical venous pO2.
Conclusions:
- Suggests a potential link between circulating GPIHBP1 levels and adverse perinatal outcomes in gestational diabetes mellitus.
Introduction:
The prevalence of gestational diabetes mellitus (GDM) is significantly increasing. Hyperglycaemia and dyslipidaemia have been demonstrated to contribute to endothelial dysfunction linked to foetal-placental circulation. Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1) is crucial for the lipolytic processing of TG-rich lipoproteins through the anchoring of lipoprotein lipase (LPL). In this study, circulating GPIHBP1 levels during pregnancy were evaluated, and their associations with hypertriglyceridaemia and the perinatal outcomes of GDM were evaluated.
Methods:
This study included 12 pregnant women with GDM and 21 pregnant women with normal glucose tolerance (NGT).
Results:
No significant differences in obstetrical outcomes were detected between the two groups. In participants with NGT, circulating GPIHBP1 levels were markedly lower in the 3rd trimester than in the 2nd trimester and at delivery. In women with GDM, circulating GPIHBP1 levels were unchanged during the 3rd trimester, and circulating GPIHBP1 levels throughout the 3rd trimester were negatively correlated with neonatal birth weight percentile and umbilical venous pO2 (ρ=-0.636, p=0.026; ρ=-0.657, p=0.020).
Discussion:
Our findings suggest a possible association between circulating GPIHBP1 levels and perinatal outcomes in patients with GDM.
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