Research on Parkinson's disease immunotherapy: a bibliometric analysis via multiple databases

Area of Science:

• Neuroscience
• Immunology
• Bibliometrics

Background:

• Parkinson's disease (PD) is characterized by neurodegeneration, alpha-synuclein aggregation, and neuroinflammation.
• Despite rapid advancements in PD immunotherapy research, a comprehensive bibliometric analysis is lacking.

Purpose of the Study:

• To conduct a bibliometric analysis of Parkinson's disease immunotherapy research.
• To identify research trends, key contributors, and emerging themes in PD immunotherapy.

Main Methods:

• Literature search in Web of Science Core Collection and Scopus.
• Bibliometric analysis using Bibliometrix software.
• Summarization of clinical trial characteristics from PubMed and trial registries.

Main Results:

• Analysis of 890 documents from 488 sources, involving 3,804 researchers across 1,483 institutions and 63 countries.
• Identification of "Parkinson's disease", "immunotherapy", and "alpha-synuclein" as frequent keywords.
• Mapping revealed two main research clusters and inclusion of 8 clinical trials focused on active immunotherapy and targeted antibodies.

Conclusions:

• The field of PD immunotherapy shows significant development potential.
• Current research emphasizes understanding pathological mechanisms and developing novel therapeutic strategies.
• Future directions include precise immunological interventions and large-scale randomized controlled trials for enhanced clinical translation.