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Related Experiment Video

Updated: May 5, 2026

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Pilot Study: Endoscopic-assisted Plasma Radiofrequency Ablation: A Minimally Invasive Strategy for Extremity

Ren Cai1, Xiangyi Wu2, Yifeng Han1

  • 1From the Department of Interventional Therapy, Multidisciplinary Team of Vascular Anomalies, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Plastic and Reconstructive Surgery. Global Open
|October 27, 2025
PubMed
Summary

Endoscopic-assisted plasma radiofrequency ablation (EPRA) is a safe and feasible minimally invasive technique for treating complex extremity lymphatic malformations (LMs). This novel approach shows promising short-term results, including functional preservation and no early recurrence.

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Area of Science:

  • Vascular Surgery
  • Minimally Invasive Techniques
  • Medical Technology

Background:

  • Lymphatic malformations (LMs) of the extremities pose significant therapeutic challenges.
  • Diffuse infiltration and high recurrence rates complicate treatment of extremity LMs.

Purpose of the Study:

  • To evaluate the feasibility and safety of endoscopic-assisted plasma radiofrequency ablation (EPRA) for complex extremity LMs.
  • To assess EPRA's efficacy in managing recurrent, multilayered LMs.

Main Methods:

  • Pilot study involving 5 patients with complex extremity LMs.
  • EPRA performed under general anesthesia using endoscopic access and radiofrequency ablation.
  • Preoperative MRI and multidisciplinary evaluation for diagnosis and mapping.

Main Results:

  • All procedures completed successfully without conversion to open surgery (mean operative time: 60 minutes).
  • No major complications observed; transient edema resolved within 1 week.
  • Short-term follow-up showed functional preservation, satisfactory cosmetic outcomes, and no early recurrence.

Conclusions:

  • EPRA is a promising alternative for extremity LMs, combining endoscopic precision with targeted ablation.
  • The technique minimizes collateral damage and risks compared to conventional treatments.
  • Feasibility and safety are supported for complex or treatment-refractory cases, warranting further research.