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Evaluation of Monocyte-lymphocyte-ratios, Changes of Patterns in Different Stages of Chronic Kidney Disease, Risks

Mumuni Alade Amisu1, Sotubo Sotomiwa2, Adegboyega Kayode3

  • 1Department of Medicine, Nephrology Unit, Ikeja, Nigeria.

The Nigerian Postgraduate Medical Journal
|October 27, 2025
PubMed

Insights

The monocyte lymphocyte ratio (MLR) is a valuable inflammatory marker for chronic kidney disease (CKD). Elevated MLR strongly correlates with worsening kidney function and disease progression in CKD patients.

Area of Science:

  • Nephrology
  • Immunology
  • Biomarker Discovery

Background:

  • Chronic kidney disease (CKD) management is costly and complex, necessitating cost-effective markers.
  • The monocyte lymphocyte ratio (MLR) serves as a surrogate for chronic systemic inflammation in CKD.
  • Elevated MLR indicates increased inflammation and immune dysfunction in CKD patients.

Purpose of the Study:

  • To investigate the correlation between MLR and the progression of CKD stages.
  • To assess MLR as a potential indicator of CKD severity.

Main Methods:

  • A cross-sectional study involving 300 CKD patients in Lagos, Nigeria.
  • CKD staging determined by estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease (MDRD) formula.
  • MLR calculated from full blood count results; data analyzed using SPSS (P < 0.05 significance).

Main Results:

  • The study included 300 CKD patients with a mean age of 58.5 years (1.6:1 male-female ratio).
  • The average MLR was 0.44 (±0.14).
  • A strong positive correlation was found between CKD stages and MLR (r = 0.763, P = 0.001). Patients in CKD stages 2 and 3 were 27.4 times more likely to be in the fourth MLR quartile compared to those on dialysis.

Conclusions:

  • Elevated MLR is significantly associated with diminished renal function across all stages of CKD.
  • MLR emerges as a potent inflammatory marker linked to CKD progression.
  • This finding supports MLR's utility in monitoring CKD severity and inflammation.
Abstract

Keywords:
Chronic kidney diseasecreatinineinflammatory biomarkersmonocyte lymphocyte ratio

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