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Chimeric fungal-firefly luciferins exhibit red shifted fungal bioluminescence
Jude I Ayogu1, Minyan Lyu1, Aleksei D Barykin2,3
1Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK. j.c.anderson@ucl.ac.uk.
Organic & Biomolecular Chemistry
|October 27, 2025
Abstract:
A rational design of new luciferins based upon the combination of luciferins from different lineages is exemplified by the synthesis of chimeric luciferins from a combination of fungal and firefly luciferin. Two new chimeric fungal-firefly luciferins exhibited the furthest red shifted bioluminescence of a fungal luciferin analogue.
