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Updated: Jan 14, 2026

Optimization of Radiochemical Reactions using Droplet Arrays
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Sequential risk and impact analyses in securing chemotherapy circuit through traceability digitalization and RFID

Kimberley Lefevre1, Amélie Andrieu1, Amandine Lassalle1

  • 1Pharmacotechnie, CHD Vendée, La Roche-Sur-Yon, France.

International Journal for Quality in Health Care : Journal of the International Society for Quality in Health Care
|October 27, 2025
PubMed
Summary
This summary is machine-generated.

Implementing barcode and RFID technologies in chemotherapy significantly reduces medication errors and improves patient safety. Risk analysis and impact assessments were crucial for a successful, secure transformation of the chemotherapy process.

Keywords:
innovationpatient safetyquality improvementrisk management

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Area of Science:

  • Healthcare Informatics
  • Patient Safety
  • Medication Management

Background:

  • Cytotoxic medications are high-risk, necessitating robust medication management to prevent errors and enhance patient safety.
  • Information technology, including barcode and radiofrequency identification (RFID) for chemotherapy bag identification, is increasingly used in healthcare.
  • This study analyzes the impact of these technologies on the chemotherapy process.

Purpose of the Study:

  • To analyze the a priori impact of barcode and RFID technologies on the chemotherapy process.
  • To identify and mitigate risks associated with the implementation of these technologies.
  • To assess the effectiveness of control measures in enhancing patient safety during chemotherapy administration.

Main Methods:

  • Sequential risk analysis across three organizational transformation stages: initial, computerized, and RFID-secured.
  • SWOT (strengths, weaknesses, opportunities, threats) analysis to identify process vulnerabilities.
  • Failure Mode and Effects Analysis (FMEA) to define corrective actions and impact analysis to prioritize bottlenecks and assess control measures.

Main Results:

  • SWOT analysis identified weaknesses and threats during the implementation phases.
  • FMEA analyzed 56 failure modes, with barcode implementation reducing unacceptable risks by 50% and RFID by 71%.
  • Impact analysis highlighted nine deployment bottlenecks, including prescription support and system configuration.

Conclusions:

  • Sequential risk and impact analysis facilitated the complex transformation of chemotherapy circuits, securing key deployment stages.
  • This approach enabled stepwise risk prioritization, strategy adjustment, and early identification of vulnerabilities.
  • Future focus will address risks related to activity discontinuity, such as system failures and cyber-attacks, exacerbated by work dematerialization.