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Related Experiment Videos

Cellular immunity in adult marasmus.

B R Bistrian, M Sherman, G L Blackburn

    Archives of Internal Medicine
    |October 1, 1977
    PubMed
    Summary

    Adult marasmus impairs cellular immune function, specifically skin test reactivity, despite intact in vitro responses. Nutritional repletion restores skin test responsiveness, indicating both malnutrition and weight loss are crucial for immune impairment.

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    Area of Science:

    • Immunology
    • Nutrition
    • Cellular Biology

    Background:

    • Adult marasmus is characterized by significant weight loss and adequate serum albumin levels.
    • Cellular immune function is often compromised in malnutrition states.

    Purpose of the Study:

    • To assess cellular immune function in adult marasmus.
    • To investigate the relationship between nutritional status, weight loss, and immune response.

    Main Methods:

    • Assessed cellular immunity via delayed hypersensitivity skin testing (Monilia, streptokinase-streptodornase).
    • Evaluated peripheral lymphocyte counts, T and B cell proportions, and in vitro lymphocyte transformation.
    • Compared immune function in marasmic patients, non-marasmic individuals with weight loss, and after nutritional repletion.

    Main Results:

    • Marasmic patients showed significantly impaired skin test reactivity but intact in vitro lymphocyte responsiveness.
    • Individuals with weight loss above the marasmus threshold (85% weight-height ratio) had no immune impairment.
    • Nutritional repletion in marasmic patients restored skin test reactivity without substantial weight gain.

    Conclusions:

    • Adult marasmus impairs delayed hypersensitivity skin test responses, indicating a specific defect in cellular immunity.
    • Both depleted nutritional status and significant weight loss are necessary for this immune impairment.
    • Adult marasmus spares protein metabolism-dependent vital functions compared to hypoalbuminemic malnutrition.

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