Cytochalasin B prevents specific sorting of reaggregating embryonic cells

The effect of cytochalasin B on specific sorting during reaggregation of embryonic chick heart and neural retina cells was studied. At a dose that did not measurably affect uptake of precursors of protein and RNA synthesis, ratios of potassium to sodium ions, and nonspecific aggregation, cytochalasin B disrupted the formation of the characteristic pattern of islands of heart cells within a retinal continuum.