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Updated: Jan 14, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

Differentiating Transient From Persistent Developmental Delays in a Nationwide Infant Cohort.

Yonatan Bilu¹, Guy Amit¹, Keren Mayer Lapidot^2,3

¹KI Research Institute, Kfar Malal, Israel.

JAMA Network Open

|October 27, 2025

Summary

This summary is machine-generated.

This study shows that routine developmental surveillance can distinguish temporary from lasting developmental delays in children. Counting unmet milestones offers an accessible method to improve early childhood development monitoring globally.

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Area of Science:

Pediatrics
Developmental Psychology
Public Health Surveillance

Background:

Early childhood developmental surveillance is crucial for timely intervention.
Current policies struggle to differentiate transient from persistent developmental delays.
This can lead to inappropriate referrals or missed support opportunities.

Purpose of the Study:

To assess if the Tipat Halav Israeli Surveillance (THIS) developmental scale can differentiate transient from persistent developmental delays.
To enhance the precision of early childhood surveillance policies.

Main Methods:

Retrospective cohort study using national Israeli maternal and child health data (2014-2022).
Included infants born at >=37 weeks gestation, assessed at 9-12 months, with at least one missed milestone.
Machine learning models and simpler decision rules were used to predict ongoing milestone attainment failure at 12-24 months.

Main Results:

In 529,797 infants, 7.1% showed developmental delays at 9-12 months.
Persistent delay was identified in 25.0% of those reassessed.
Machine learning models achieved areas under the ROC curve of 0.71-0.77; counting unmet domains showed good sensitivity and specificity.

Conclusions:

Routine surveillance data can effectively distinguish transient from persistent developmental delays.
Counting unmet developmental domains is a valid and practical approach.
This offers an accessible method to improve developmental surveillance and child outcomes worldwide.