Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Analysis of clinical and imaging predictors of response to corticosteroid therapy in inflammatory dacryoadenitis.

Orbit (Amsterdam, Netherlands)·2026
Same author

Predictors of Cerebral Small-Vessel Disease in Middle-Aged, Virologically Controlled People Living With HIV.

Open forum infectious diseases·2026
Same author

Re: Dones et al.: Emergency department use of ocular point-of-care ultrasound and its utility in diagnosis at a tertiary academic medical center (Ophthalmology. 2026;133:720-727).

Ophthalmology·2026
Same author

Combination of color-Doppler ultrasound and MRI to improve lacrimal gland lesion characterization: A machine learning approach.

Diagnostic and interventional imaging·2026
Same author

Intereye differences in myopic macular degeneration, intraocular pressure and axial length: the Two-Continent Eye Study.

The British journal of ophthalmology·2026
Same author

Radiological management of reversible cerebral vasoconstriction syndrome (RCVS) in France: a national multicenter survey.

AJNR. American journal of neuroradiology·2026

Related Experiment Video

Updated: Jan 14, 2026

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
12:23

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

14.5K

Rethinking routine lumbar puncture in isolated optic neuritis: results from a large cohort study.

Romain Deschamps1, Marine Boudot de la Motte2, Emeline Chaugne2

  • 1Department of Neurology, Hôpital Fondation Adolphe de Rothschild, Service de Neurologie, Fondation Ophtalmologique Adolphe de Rothschild, 25 Rue Manin, 75019, Paris, France. rdeschamps@for.paris.

Journal of Neurology
|October 27, 2025
PubMed
Summary

Routine lumbar puncture (LP) offers minimal diagnostic value for optic neuritis (ON) without multiple sclerosis (MS)-like MRI findings. Prioritizing MRI and antibody tests over LP can expedite diagnosis and treatment for ON patients.

Keywords:
MRIMultiple sclerosisMyelin oligodendrocyte glycoproteinOptic neuritisSarcoidosis

More Related Videos

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.8K
Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats
06:30

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

881

Related Experiment Videos

Last Updated: Jan 14, 2026

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
12:23

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

14.5K
Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.8K
Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats
06:30

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

881

Area of Science:

  • Neurology
  • Ophthalmology
  • Immunology

Background:

  • Lumbar puncture (LP) is often recommended for isolated optic neuritis (ON) when brain MRI lacks multiple sclerosis (MS)-suggestive lesions.
  • The clinical utility of LP is uncertain given advancements in serological and imaging diagnostics.

Purpose of the Study:

  • To evaluate the diagnostic yield of LP in acute/subacute ON without MS-like brain MRI findings.
  • To assess the impact of LP on treatment timing in this patient cohort.

Main Methods:

  • Retrospective monocentric study of 184 adult patients with acute/subacute ON and no MS-like brain MRI lesions.
  • Analysis included final etiological diagnoses, LP's contribution, and treatment initiation delays.

Main Results:

  • Idiopathic ON (48.4%) was most common, followed by MOGAD (22.3%) and MS (19.6%).
  • LP contributed to the final diagnosis in only 2.2% of cases (2 MOGAD, 2 CLL-related ON), always with other tests.
  • Spinal/orbital MRI and antibody testing were crucial; LP did not significantly expedite corticosteroid treatment.

Conclusions:

  • Routine LP has minimal diagnostic yield in isolated ON without MS-typical MRI findings.
  • A selective diagnostic approach prioritizing MRI and antibody testing over systematic LP is recommended.
  • This strategy may prevent treatment delays in ON patients.