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Published on: July 27, 2022
The epigenetic factor Zrf1 regulates intestinal stem cell proliferation during midgut regeneration
Joshua Shing Shun Li1, Ying Liu1, Ah-Ram Kim1
1Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America.
None:
Stem cells are essential for tissue maintenance and regeneration, balancing self-renewal and differentiation to support homeostasis and repair. Through an RNAi screen in the Drosophila midgut, we identified the epigenetic factor Zrf1 as a critical regulator of intestinal stem cell (ISC) proliferation. Functional analyses reveal that Zrf1 integrates inputs from multiple signaling pathways and interacts with components of the RNA-induced silencing complex (RISC). Our findings suggest that Zrf1 is potentially a key chromatin regulator necessary for maintaining stem cell proliferation, enhancing our understanding of the molecular controls underlying stem cell function and chromatin-associated defects.
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