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Pharmacokinetics: Drug–Drug Interactions01:25

Pharmacokinetics: Drug–Drug Interactions

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Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...
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Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence01:19

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Pharmaceutical products contain more than just the active drug; they also contain various excipients such as binders, solubilizers, stabilizers, preservatives, and other elements. In some cases, impurities or contaminants might be present. Traditionally, quality control in pharmaceuticals has primarily focused on the analysis of the active drug, often overlooking the impact of these additional components. The recent issue with heparin contamination by over-sulfated chondroitin sulfate, a...
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Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Pharmacokinetics: Drug–Food and Drug–Viral Interactions01:26

Pharmacokinetics: Drug–Food and Drug–Viral Interactions

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A drug interaction occurs when the concurrent use of another drug, food, or an external substance alters the pharmacological activity of a drug. This interaction can modify the action of the original drug, affecting its effectiveness and safety.Drug–food interactions are significant as they impact drug absorption, metabolism, and excretion. For example, grapefruit juice is a well-known disruptor of drug metabolism. It inhibits the cytochrome P450 3A4 enzyme, crucial for the metabolism of...
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Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

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Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
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Biopharmaceutical Factors Influencing Drug Product Design: Overview01:22

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Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though...
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Experimental Quantification of Interactions Between Drug Delivery Systems and Cells In Vitro: A Guide for Preclinical Nanomedicine Evaluation
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Pharmacoinformatics in Drug-Excipient Interactions.

Sourav Chougule1, Kanika Manchanda2, Mehak Sood3

  • 1Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, S.A.S. Nagar, Punjab 160062, India.

Molecular Pharmaceutics
|October 27, 2025
PubMed
Summary
This summary is machine-generated.

Pharmacoinformatics, combining computational methods like quantum chemistry, molecular modeling, and AI, significantly enhances drug-excipient interaction studies. This approach streamlines formulation development by revealing molecular behavior and interaction mechanisms for improved drug stability and performance.

Keywords:
artificial intelligencedissolutionmolecular modelingnoncovalent interactionsquantum chemistrysolubilitystability

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Area of Science:

  • Pharmaceutical Sciences
  • Computational Chemistry
  • Drug Development

Background:

  • Drug-excipient interactions are crucial for formulation stability and biopharmaceutical performance.
  • Selecting compatible excipients is key for optimal drug product development.
  • Traditional experimental methods are now augmented by advanced computational approaches.

Purpose of the Study:

  • To highlight the role of pharmacoinformatics in drug-excipient interaction studies.
  • To discuss advancements and future directions in computational approaches for formulation design.
  • To emphasize the benefits of computational methods in understanding molecular interactions.

Main Methods:

  • Utilizing quantum chemical calculations for electronic/atomic-level insights.
  • Employing molecular modeling for visualization and simulation of dynamic behavior.
  • Leveraging artificial intelligence (AI) models for enhanced excipient screening.

Main Results:

  • Computational tools effectively aid in preformulation studies and excipient screening.
  • These methods provide insights into drug-excipient complex properties impacting biopharmaceutical performance.
  • Recent studies confirm the applicability of computational tools in predicting stability and interactions.

Conclusions:

  • Pharmacoinformatics offers significant advantages in streamlining drug formulation development.
  • Understanding molecular behavior and interaction mechanisms is facilitated by computational methods.
  • The integration of pharmacoinformatics is pivotal for future advancements in pharmaceutical research.