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Modeling Control of Invasive Fire Ants by Gene Drive.

Yiran Liu1, Samuel E Champer2, Benjamin C Haller2

  • 1Center for Bioinformatics, Center for Life Sciences, School of Life Sciences, Peking University, Beijing, 100871, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
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PubMed
Summary
This summary is machine-generated.

Gene drive technology shows promise for controlling invasive fire ants (Solenopsis invicta). While challenges exist, novel strategies can enhance effectiveness against both colony types, aiding native species recovery.

Keywords:
colony structurescomputational modelingfire antsgene drivessuppression

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Area of Science:

  • Ecology and Evolutionary Biology
  • Genetics and Genetic Engineering
  • Invasive Species Management

Background:

  • The red imported fire ant (Solenopsis invicta) is a highly invasive species with aggressive behavior, making traditional control methods insufficient.
  • Ants present unique challenges for gene drive due to their complex colony structures (monogyne and polygyne) and haplodiploid genetics.

Purpose of the Study:

  • To model the effectiveness of homing suppression gene drive in fire ant populations.
  • To explore strategies for overcoming gene drive limitations in haplodiploid organisms and assess the impact of interspecific competition.

Main Methods:

  • Development of a spatially explicit model simulating gene drive dynamics in monogyne and polygyne fire ant colonies.
  • Evaluation of standard suppression drives, novel strategies (dominant-sterile resistance, two-target drives, colony structure modification), and interspecific competition.

Main Results:

  • Gene drive effectively eliminates polygyne colonies over time, with monogyne populations persisting at lower levels.
  • Modified gene drive strategies (e.g., dominant-sterile resistance, two-target approaches) can restore high suppressive capability in haplodiploids.
  • Interspecific competition can enhance gene drive efficacy, particularly during initial invasion phases, facilitating native species recolonization.

Conclusions:

  • Gene drive is a promising long-term strategy for fire ant suppression, even with imperfect efficiency.
  • Targeting conserved female fertility genes offers potential for efficient, low-resistance gene drive designs.
  • Gene drive interventions, combined with ecological factors, could aid in restoring native habitats.