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Using large language models to automate summarization of CT simulation orders in radiation oncology
Meiyun Cao1, Shaw Hu2, Jason Sharp1
1Department of Radiation Oncology, Mayo Clinic Hospital, Phoenix, Arizona, USA.
Journal of Applied Clinical Medical Physics
|October 27, 2025
Summary
Large language models (LLMs) can automate the summarization of Computed Tomography (CT) simulation orders in radiation oncology. This AI-powered approach enhances efficiency and accuracy, reducing therapist workload and improving workflow.
Area of Science:
- Radiation Oncology
- Artificial Intelligence
- Medical Informatics
Background:
- Radiation oncology therapists manually summarize Computed Tomography (CT) simulation orders.
- Manual summarization increases workload, introduces variability, and is prone to human errors.
Purpose of the Study:
- To address challenges in manual CT simulation order summarization.
- To automate summary generation using a large language model (LLM).
- To evaluate the performance of an LLM for this task.
Main Methods:
- Collected 607 CT simulation orders from the Aria database.
- Utilized a LLaMa 3.1 405B model via API for keyword extraction and summary generation.
- Developed customized prompts collaboratively with therapists and validated summaries against ground truth.
Main Results:
- LLM-generated summaries achieved over 98% accuracy compared to ground truth.
- Demonstrated improved consistency in format and enhanced readability.
- Showed consistent performance across diverse treatment modalities and disease sites.
Conclusions:
- LLMs, specifically LLaMa 3.1 405B, precisely and consistently summarize CT simulation orders.
- LLMs show significant potential to assist therapists, reduce workload, and enhance radiation oncology workflow efficiency.

