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Rosai-Dorfman Disease of the Breast: Radiologic-Pathologic Correlation.

Kathryn W Zamora1, Stefanie Zalasin1, Ami Desai1

  • 1Department of Radiology, University of Alabama Birmingham, Birmingham, AL, USA.

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Summary

Rosai-Dorfman disease (RDD) is a rare breast condition. Familiarity with its imaging is crucial for radiologists, as diagnosis often relies on breast biopsy and imaging characteristics.

Keywords:
Rosai-Dorfman diseasebreast pathologynon-Langerhans cell histiocytosis

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Area of Science:

  • Histiocytosis
  • Oncology
  • Radiology

Background:

  • Rosai-Dorfman disease (RDD) is a rare non-Langerhans cell histiocytosis.
  • It primarily affects lymph nodes but can occur in extranodal sites, including the breast.
  • Literature on RDD's breast imaging presentation is limited.

Purpose of the Study:

  • To describe the imaging presentation of Rosai-Dorfman disease in the breast.
  • To highlight the importance of recognizing RDD in breast imaging.
  • To inform radiologists about diagnostic and management considerations.

Main Methods:

  • Review of existing literature on RDD in the breast.
  • Analysis of mammographic and ultrasound imaging characteristics.
  • Discussion of treatment approaches and multidisciplinary care.

Main Results:

  • RDD in the breast often presents as a palpable mass (two-thirds) or is found on screening mammography (one-third).
  • Mammographically, RDD typically appears as oval masses with indistinct margins.
  • Ultrasound findings usually involve irregular masses with indistinct margins.

Conclusions:

  • Breast imaging radiologists must be aware of RDD's imaging features for potential early diagnosis via biopsy.
  • Treatment is tailored to extent, with many cases resolving spontaneously or managed conservatively.
  • Multidisciplinary consultation is vital for optimal management of RDD involving the breast.