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A Mouse Model of Ankle-Subtalar Complex Joint Instability
Published on: October 28, 2022
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[Research progress on central nervous system changes in chronic ankle instability and its implications for treatment]
1Department of Sports Medicine, Peking University Third Hospital, Institute of Sports Medicine of Peking University, Beijing Key Laboratory of Sports Injuries, Engineering Research Center of Sports Trauma Treatment Technology and Devices, Ministry of Education, Beijing 100191, China.
Zhonghua Yi Xue Za Zhi
|October 27, 2025
Summary
Chronic lateral ankle instability (CLAI) is linked to central nervous system (CNS) functional changes affecting neuromuscular control and sensory-pain. New treatments targeting CNS function offer improved conservative care for CLAI patients.
Area of Science:
- Neuroscience
- Orthopedics
- Sports Medicine
Background:
- Chronic lateral ankle instability (CLAI) is a common condition.
- Previous research suggests central nervous system (CNS) dysfunction may contribute to CLAI-related impairments.
- Advancements in research techniques have provided new insights into CNS involvement.
Purpose of the Study:
- To review recent research (last five years) on CNS function changes in CLAI patients.
- To summarize the understanding of CNS alterations in CLAI.
- To highlight emerging CNS-targeted treatments for CLAI.
Main Methods:
- Literature review of studies published in the past five years.
- Analysis of research on central nervous system function in chronic lateral ankle instability.
- Synthesis of findings related to neuromuscular control and sensory-pain mechanisms.
Main Results:
- Ankle dysfunction in CLAI is associated with CNS functional abnormalities.
- Key areas of change include neuromuscular control and sensory-pain pathways.
- Emerging evidence supports CNS involvement in CLAI pathophysiology.
Conclusions:
- CNS functional changes are increasingly recognized as significant in CLAI.
- Targeting CNS function presents promising avenues for conservative treatment.
- Further research can refine neurological interventions for CLAI management.

