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Published on: July 10, 2018
Refining mild asthma phenotyping with FeNO: a population-based evaluation
Charmaine J M Lim1,2, Marie-Kathrin Breyer3,4, Emiel F M Wouters3,5,6
1Ludwig Boltzmann Institute for Lung Health, Vienna, Austria. charmaine.helk-lim@leadstudy.at.
Abstract:
The utility of fractional exhaled nitric oxide (FeNO) was evaluated alongside blood eosinophils in phenotyping mild asthma. Inclusion of FeNO improved classification accuracy and calibration in an adapted ISAR-based model; however, its predictive improvement was modest and its susceptibility to transient elevations suggests limited added value for routine clinical classification. Simplified algorithms may offer more accurate phenotyping in population-based settings with real-world constraints.
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